The Importance of Accounting for Time-Related Bias in Single-Arm Trials with Historical Controls (Part 1)
Randomized control trials (RCTs) are typically heralded as the gold standard in clinical trial design. However, regulatory agencies are increasingly recognizing the role of single-arm trials that leverage historical controls, especially within the rare disease space. Yet while these single-arm trials could have important ramifications for getting much-needed drugs to market quicker, pharma companies need […]